3,4,5-Tricaffeoylquinic acid ( —— )

产品货号. M31111 CAS No. 86632-03-3

3,4,5-Tricaffeoylquinic acid may attenuate the TNF-α±- and LPS-stimulated production of inflammatory mediators in keratinocytes by suppressing the Toll-like receptor 4 expression-mediated activation of the Akt, ERK and NF-κB pathways, it may exert an inhibitory effect against the pro-inflammatory mediator-induced skin disease.

纯度: >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

规格	价格/人民币	库存	数量
5MG	￥4040	有现货
50MG	获取报价	有现货
100MG	获取报价	有现货

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生物学信息

产品名称

3,4,5-Tricaffeoylquinic acid
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

3,4,5-Tricaffeoylquinic acid may attenuate the TNF-α±- and LPS-stimulated production of inflammatory mediators in keratinocytes by suppressing the Toll-like receptor 4 expression-mediated activation of the Akt, ERK and NF-κB pathways, it may exert an inhibitory effect against the pro-inflammatory mediator-induced skin disease.
产品描述

3,4,5-Tricaffeoylquinic acid may attenuate the TNF-α±- and LPS-stimulated production of inflammatory mediators in keratinocytes by suppressing the Toll-like receptor 4 expression-mediated activation of the Akt, ERK and NF-κB pathways, it may exert an inhibitory effect against the pro-inflammatory mediator-induced skin disease.
体外实验

3,4,5-Tricaffeoylquinic acid (0-50 μM) reduces TNF-α-induced production of cytokines in HEK001 keratinocytes. 3,4,5-Tricaffeoylquinic acid (15 μM, 35 min) inhibits TNF-α-induced IkBα phosphorylation and activation of NF-κB. Cell Viability Assay Cell Line:Keratinocytes Concentration:15, 25 and 50 μM Incubation Time:24 hours Result:Cell death was cell ～4-5% at 15 and 25 μM, ～9% at 50 μM.Western Blot Analysis Cell Line:Keratinocytes Concentration:15 μM Incubation Time:20 min before 10 ng/mL TNF-α addition for 15 min Result:Decreased TNF-α-induced-IkBα phosphorylation of IkBα and levels of cytosolic NF-Κb p65, cytosolic NF-Κb p65.
体内实验

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同义词

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通路

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靶点

Other Targets
受体

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研究领域

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适应症

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